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KMID : 1149120230200010017
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Journal of the Korean Society for Psoriasis
2023 Volume.20 No. 1 p.17 ~ p.21
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Generalized Pustular Psoriasis in a 7-year-old Boy
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Seong Hyun-Kyong
Oh Seon-A
Lee Su-Min
Park Hai-Jin
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Abstract
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Generalized pustular psoriasis (GPP) is a severe form of psoriasis presenting widespread pustules on erythematous background with fever. GPP is extremely rare in children.
Due to its rarity, few evidence-based studies on treating pediatric GPP exist, and no established guidelines.
A 7-year-old boy presented with scaly erythematous patches on the axillae, neck, scalp, and legs that occurred two years ago. After a skin biopsy, he was treated with topical tacrolimus under the diagnosis of psoriasis . Six months later, he developed sterile pustules on erythematous patches over the whole body with a fever. Skin biopsy showed subcorneal macropustules and large Munro’s abscess compatible with GPP. He was treated with intravenous methylprednisolone and oral cyclosporin. However, there was no significant improvement, so we used adalimumab. After the treatment, his skin lesions gradually improved without any complications. Herein, we report a rare case of GPP in a child treated with adaliumab.
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KEYWORD
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Adalimumab, Child, Generalized pustular psoriasis
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